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KMID : 0370020000140000075
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Chung-Ang Journal of Pharmacal Sciences
2000 Volume.14 No. 0 p.75 ~ p.82
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Pharmacokinetic Study of Omeprazole-cholestyramine Resin suppository in Rabbits
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Abstract
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We have performed the pharmacokinetic study of omeprazole- cholestyramine resinate in rabbits, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. In this experiments, omeprazole-cholestyramine resinate suppository seemed to have more rapid absorption than omeprazole. AUC and C_max of omeprazole-cholestyramine resinate were 2.3 and 3.7 times greater than omeprazole, respectively. T_max was almost half of omeprazole. Compared with i.v. bolus, i.v. infusion showed three times greater bioavailability. As a result omeprazole-cholestyramine resinate suppository had 74% bioavailability of i.v. infusion, suggesting i.v. infusion could be replaced by suppositories.
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